The Kang Lab is interested in the development of novel strategies for the induction of transplant-specific tolerance in order to control transplant rejection without long-term global immunosuppression.  We have several projects that each focus on different means of achieving this ultimate goal.  In one project, we are working with specialized immune cells called dendritic cells to learn how to specifically suppress only the white blood cells that attack the transplanted organ in a recipient.  Other developments include genetically engineering cell lines in order to determine quantitative and mechanistic information about the roles of two different types of white blood cells in rejection.